Wednesday, February 22, 2012

In developed countries, it appears in. ..

1947, George Orwell was admitted to hospital in the Scottish case of galloping consumption. Orwell was first diagnosed with tuberculosis 10 years ago, but nevertheless, that the biographer called one of the many foolish decisions in life littered misjudgements, he recently moved to a remote and primitive Scottish cottage, where he began working on


Nineteen Eighty-Four. There he developed night sweats, fever, weight loss, which are signs of active TB. By the time he was admitted to hospital


mycobacterium tuberculosis was milled about 30 pounds from his already thin frame. When I was young and romantic, I thought that TB did you a good writer. Eventually, so many great, from Keats to Chekhov in all three Bronts, seemed strattera cost dead. Indeed, in the 19th century in Europe, White plague can cause more than a quarter of all deaths. Although this figure has decreased the time Orwell, Camus writers to Bukovski before TB infection, as millions of lesser-known compatriots. Only antibiotics finally conquered the disease. Victory came just too late for Orwell. His friends actually managed to get a stock of streptomycin, a new TB drug from America, but it caused such a violent reaction that every morning when he woke up blood from ulcers in the mouth was glued her lips shut. This was to be soaked before he could speak. After several weeks, his doctors had to give up. Less powerful new drug called PAS, which he tried in 1949, makes it so sick, but apparently not very concerned about the TB bacteria, either. In January 1950, broke into an artery in the lungs, and at the age of 46 years, George Orwell drowned in his own blood. It seems medieval very end of modern man. But we have not so far from tuberculosis, as we like to think. It remains endemic in developing countries and returns to the richer countries through travel and immigration, and the phenomenon, Alexander Fleming who discovered penicillin, warned in 1940: resistance to antibiotics. What people may not know about the resistance, said Eric Utt, a former researcher of antibiotics is currently working at Pfizers science policy unit is that the resistant organisms already there. That is why we find bacteria that are resistant to antibiotics, new, even before these products hit the market. Theyre often alone in the corner with a mutation that is happening on the immunity of some super-drug. When we bombard them with deadly weapons competition, they will place themselves, and eventually they take over. After this generation, super-drug loses its effectiveness. Moreover,


other drugs lose their effectiveness because many bacteria resistant to one drug protystoyatymut other drugs of the same class. At present, we found that genes of bacteria deal with each other indiscriminately, even between different species, so that the resistance developed a strain of bacteria can be acquired by another. The more we use these drugs, the sooner they begin to fail. By 2004, more than 50 percent of staph infections were caused by methicillin-resistant Staphylococcus aureus


(MRSA), compared with 2 percent in 1987, and some also resistant to vancomycin, common antibiotics backup. Other organisms of diseases show that the same model: pneumococcus,


Escherichia coli, and so M. tuberculosis



currently members of the multidrug-resistant and extensively drug-resistant varieties. In 2001, the Food and Drug Administration warned:


If antibiotic resistance problems are defined as they appear, and steps are taken to keep them, the world may face a previously treatable diseases that have again become untreatable, as in the days before antibiotics were developed. We are not quite on the verge of some gloomy Victorian future. But every year, the forecast for infectious diseases patients is slightly worse. Ramanan Laxminarayan, an economist of the Center for Disease Control dynamics, economic policy, said that even extremely drug-resistant TB can be treated with several drugs. Theyre just extremely toxic, and not what Theyre youd want takethink blood lips compressed. A more powerful drugs are usually more expensive than older drugs. Now cost hundreds of dollars, and the next step will be thousands of dollars, Laxminarayan said. In developed countries, manifested in his slightly above average cost of antibiotics. In poorer countries, it appears as more people get sick and die of persistent infections. Even in rich countries, death from infection is still a threat, MRSA only kills thousands every year. And the company is developing antibiotics as fast as before. According to the Infectious Diseases Society of America (IDSA), between 1983 and 1987 the FDA approved 16 new antimicrobials for use in people from 2003 to 2007, it approved a six. Who is to blame for it all depends on who you ask. Patients, doctors, hospitals, pharmaceutical companies, regulators and even all taken their turn at the dock. But the economist, when all the guilt, it is really not the same bug that witnessed not a personal failure, but failure of the market. Almost no one develops a kind of MRSA in your own body. Resistance occurs over many generations of treatment, usually in hospitals with many patients. Despite the resistance, ultimately unavoidable, we can slow down its appearance significantly. However, it requires strict adherence to the tedious and often costly protocols. Each slip contributes only slightly to the problem, so Theres a high temptation to free ride:


Just this once, Ill skip to wash their hands between patients or


Just today, Ill miss the last pills upset my stomach. Anyone who lived in the house in a group of college knows how the story goes. Markets and property rights, to give people incentives to prevent the tragedy of Commons, and gave a steady stream of vital medicines and medical innovation. But antibiotics are different from most other products we use. Kevin Outterson, professor of health law and bioethics at Boston University, said, 100 million people may take Lipitor and it will be just as effective as the day it was invented. If we find something even better, patients can still take Lipitor in 1000. But antibiotics like penicillin will inevitably begin to lose efficiency. .

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